November 7, 2018 – REGENXBIO announced that the first subject was dosed at the Children’s Hospital of Pittsburgh by a medical team led by Dr. Maria Escolar, Associate Professor of Pediatrics, Director of Program for the Study of Neurodevelopment in Rare Disorders at the Children’s Hospital of Pittsburgh and primary investigator for the Phase I/II clinical trial of RGX-121 for the treatment of MPS II. Additional subject recruitment and site activation continues. The next program updates are expected in 2019.